Experience the first and only kinase inhibitor profiling service that gives you precise Kd values for your compounds on a full human kinome scale. Powered by our proprietary DIANA technology, we provide:
Download the complete DB Kinase Panel™ assay list here!
Download the full DIANA Kinase Inhibitor Profiling booklet here!
Services
DB Kinase Panel™
DB Kinase Panel™ is our flagship profiling package, covering over 170 kinases across the entire human kinome. Powered by proprietary DIANA technology, each run delivers true binding constants (Kd) for every kinase making DB Kinase Panel™ the only tool on the market for quantitative potency determination at full kinome scale.
DB MiniKinase Panel™
The DB MiniKinase Panel™ is a precision-engineered set of 48 assays designed to represent the entire human kinome. By leveraging a proprietary optimization algorithm and inhibition "fingerprints" from over 257 kinases, this panel maximizes coverage while minimizing your screening footprint. Profile smarter with the industry's most efficient representative set.
DB Focused Panels™
We are continuously expanding the portfolio of assays in our kinase panel. We started with a set of assays that together provide a representative coverage of the entire human kinome. Currently, we are focusing on completing smaller, coherent groups of assays that can function as focused subpanels of our flagship product, the DB Kinase Panel™, gathered under our DB Focused Panel™ brand.
DIANA CDK Panel
DIANA CDK panel is an advanced kinase inhibitor selectivity profiling tool which comprise 24 different CDK/cyclin complexes. Using proprietary DIANA technology it delivers quantitative affinity measurements (Kd) from single measurement.
DIANA CK1 Panel
DIANA CK1 panel is an advanced CK1 (casein kinase 1) inhibitor selectivity profiling tool which comprise 7 different CK1s. Using proprietary DIANA technology it delivers quantitative affinity measurements (Kd) from single measurement.
DIANA TK Panel
DIANA TK panel is an advanced tyrosine kinase inhibitor selectivity profiling tool which comprise 69 different TKs. Using proprietary DIANA technology it delivers quantitative affinity measurements (Kd) from single measurement.
Pricing of DIANA Kinase Inhibitor Profiling Services
Product Name | No. Kinases | Cpds | Price (EUR) | Price per kinase (EUR) | Turnaround Time** | Result |
|---|---|---|---|---|---|---|
+170† | 1 | 2500 | 15 | 14 business days | Dissociation constant (Kd) | |
48 | 2 | 1440*** | 20 | 7 business days | Dissociation constant (Kd) | |
70 | 1 | 1360 | 20 | 7 business days | Dissociation constant (Kd) | |
24 | 1 | 480 | 20 | 7 business days | Dissociation constant (Kd) | |
7 | 1 | 140* | 20 | 7 business days | Dissociation constant (Kd) | |
Custom selection | 1 | 1 | 25* | 25 | 7 business days | Dissociation constant (Kd) |
*Minimal Order Quantity for Custom Selection service is 500 EUR.
**Counts from the day compounds are delivered to our testing facility. For complex orders the turnaround time can be extended to 14 business days.
***DB MiniKinase Panel can be ordered also for 1 cpds for 960 EUR.
†The list of kinases is constantly growing. For the most recent info, download the current list of kinases.
All prices exclude VAT.
Service without compromises
DIANA Assay: Accelerate Your Project and Get Quantitative Potency Data from the Start!
Quantitative potency data for the price of relative potency data
7 business days for standard and 14 business days for complex services
You can assemble your own kinase panel for comparable price as our focused panels
Our kinase assay portfolio representatively covers all kinase families within human kinome
Kamil Paruch, PhD
Associate Professor at Masaryk's University
Lukáš Górecki, PhD
Biomedical Research Centre, University Hospital Hradec Králové
Technology Intro
DIANA is a solid-phase competitive binding assay that uniquely combines small molecule-based DIANA probes with the strengths of ELISA and qPCR, delivering robust quantitative potency data with an exceptionally broad dynamic range. This allows researchers to obtain precise binding affinity constants (Kd) from the start of their projects at a cost comparable to conventional methods that only provide relative inhibition.
DIANA Assay
DIANA assay measures potency of tested compound as function of its competition with DIANA probe. The assay delivers true binding constants (Kd) of test compound.
DIANA Assay
The amount of displaced DIANA probe is quantitatively determined by qPCR. qPCR readout ensures high dynamic range and enables calculation of Kd from a single measurement.
DIANA Assay
Similar assay setup yields highly comparable results between the methods. Usage of recombinant kinases instead of phage constructs ensures easier kinase quality control and consistency of results.
Consultation
Not sure what you precisely need? Are you seeking an advice to your problems? Feel free to contact us to schedule consultation with our specialist directly.
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