DB RNase Inhibitors: Unique protection with DB Ultima H!

We are devoted to improve direct RT-PCR and other RNA-based applications and we understand know important it is to protect RNA from degradation.


RNase inhibitors are the only way to protect RNA across a wide range of applications. However, all protein inhibitors are highly unstable, while synthetic inhibitors have low potency and low assay compatibility. As a result, none of them reliably protect RNA.


That is why we developed DB Ultima H RNase inhibitor – a breakthrough, highly engineered human RNase inhibitor with optimal inhibition profile and outstanding stability. It is the most potent inhibitor of human RNases and potently inhibits also other eucaryotic and E.coli RNases. It sets a new benchmark in reliability through unprecedented oxidative resistance and stability across a wide range of assay conditions. It strongly outperforms other inhibitors in direct RT-PCR, RNA-seq, in vitro transcription and other applications.


Our portfolio also features a unique DB Bovine RNase inhibitor. All our inhibitors are of exceptional purity and recombinantly expressed in E. coli.


We created the complete catalogue of our RNase inhibitors, PCR and RT-PCR mixes and enzymes. Find everything you need HERE.

PRODUCTS

DB RNase Inhibitors: Complete solution for RNA protection

Unique approach to the RNase inhibition! Bovine variant offers a remarkable stability with fewer cysteine residues, ensuring consistent performance and oxidation resistance.

Unique approach to the RNase inhibition! Bovine variant offers a remarkable stability with fewer cysteine residues, ensuring consistent performance and oxidation resistance.

The best option for samples of human origin against RNases A, B and C. Recombinant protein from E. coli

The best option for your everyday work. The golden standard of RNase inhibition.

Key Parameters

DB Ultima H: The most potent inhibitor on the market!


Full oxidative resistance


Retains activity without DTT. Fully active even at 2% H₂O₂.

Exceptional thermostability


The only protein RNase inhibitor stable above 55 ℃!

High buffer/storage stability


Stable at room temperature in usual PCR buffers for months.

Suitable for direct RT-PCR


Even higher activity than human RNase inhibitor in human tissues!

Selection Guide

Name (Cat. no.)

Inhibition of Human RNases

Oxidative stability

Storage stability

Thermal stability

Origin

DB Ultima H RNase Inhibitor (DB-1306)

Recombinant

DB RNase Inhibitor Human (DB-1259)

Recombinant

DB RNase Inhibitor Bovine (DB-1260)

Recombinant

DB RNase Inhibitor Porcine (DB-1261)

Recombinant

References

Citations and Publications

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