DIANA technology is best suited for high throughput screening of small-molecular libraries for inhibitors of enzymes (or other functional proteins) or protein-protein interactions in drug discovery projects. In this setup, screened compounds compete with the probe for the target binding. It offers sensitive hit discovery (ultra-low false-positive and false-negative rate) while providing direct quantification of the compound’s inhibition potency. It also allows highly efficient screening of pooled libraries leading to a reduced screening cost and time. This makes it suitable not only for both large pharma high-throughput-screening facilities abut also for smaller-scale projects at academic institutions (in-house libraries of ~10k compounds can be screened in just few 96-well plates).
DIANA can also be used for selection of candidates with the highest specificity towards the certain member from the closely-related protein family. This is utilized in DIANA selectivity panels such as DIANA carbonic anhydrases panel.
We have a high success rate even or a difficult targets
We are able to provide you the HTS service in 3 months
Assay development available as stand-alone service or as part of collaborative projects
Minimal performance criteria and risk-sharing commercial models possible
Download the complete HTS Leaflet
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DIANA Technology for HTS
DIANA Biotechnologies offers HTS projects run at their specialized screening facility, utilizing an in-house library of ~150,000 compounds. Customer or third-party compound libraries are also accepted, and compounds can be screened in pooled setups for easier logistics and higher confidentiality. The assay provides accurate inhibition potency measurements, with hits ranked by affinity and validated using known inhibitors. Full data analysis and interpretation are included, with short turn-around times and competitive pricing.
