siRNA

siRNAs are used in molecular biology to silence gene expression post-transcriptionally and are widely used in functional genomics studies, therapeutic development, and drug target validation. Their ability to selectively silence genes makes siRNAs a powerful tool for understanding gene function and developing treatments for various diseases, including cancers, viral infections, and genetic disorders.

LNA

LNA’s unique chemical structure enhances the thermal stability and binding affinity to their complementary DNA or RNA sequences resulting in increased specificity and resistance to nuclease degradation compared to traditional DNA or RNA molecules. These properties make LNAs highly effective in applications such as antisense therapy, gene silencing, microRNA research, and in situ hybridization. Additionally, LNA probes are used in quantitative PCR (qPCR) assays to improve detection sensitivity and accuracy. Increased maximum annealing temperature and improved specifity and affinity in base-pairing

TaqMan Probes

TaqMan™ probes is the golden standard of PCR assays. TaqMan probes provide high specificity, sensitivity, and quantification accuracy, which makes them indispensable in many research and diagnostics applications. We offer a wide range of dyes and quenchers at a highly competitive price:

Standard fluorescent dyes (FAM, HEX, TAMRA, ROX, TEX, Cy5, and Cy5.5) for terminal labeling.

Dabcyl and Black Hole Quenchers (BHQ-1, BHQ-2, BHQ-3) for terminal and internal (phosphate- or thymine-linked) labeling.

Other modifications

Attachment chemistry: biotin and functional groups for efficient amine-NHS or thiol-maleimide coupling.

Click chemistry: unique modifications for copper-catalyzed (PEG- or free alkyne and azide groups) or copper-free (DBCO and TCO groups) click reaction.

Abasic sites, spacers and non-standard bases (dI, dU).

Mixed bases for synthesis of DNA libraries.

All modifications can be introduced to 5′ end, 3′ end or internally.