Carbonic anhydrases (CA) are a diverse family of zinc metalloenzymes, which play essential roles in various physiological processes such as respiration, pH regulation, and CO₂ transport. Several CA isoforms are validated drug targets with their inhibitors being already on the market (such as Acetazolamide or Brinzolamide).
Leveraging our proprietary DIANA technology (DNA-linked Inhibitor Antibody Assay), we introduce the DIANA Carbonic Anhydrase Panel. First, commercially available CA inhibitors selectivity profiling service that enables simultaneous assesement of CA inhibitor potency against all 11 enzymatically active human CA isoforms.
Would you like to see the full DIANA CA Panel leaflet? Download it here!
Service without compromises
DIANA Assay: Accelerate Your Project and Get Quantitative Potency Data from the Start!
Quantitative potency data for the price of relative potency data
7 business days for standard and 14 business days for complex services
You can assemble your own kinase panel for comparable price as our focused panels
Our CA assay portfolio representatively covers all enzymatically active CAs
Pricing information
Name | Price | Delivery Time | Result |
|---|---|---|---|
DIANA CA Panel | 500 EUR for 1 cpd* | 7 business days*** | Dissociation constant (Kd) |
Custom selection | 25** | 7 business days | Kd |
*Fully customizable based on customer needs, with tailored quotes available.
**Minimal Order Quantity for Custom Selection service is 500 EUR.
***Turnaround time starts from the day compounds are received at our facility. For complex orders the turnaround time can be extended to 14 business days.
Technology Intro
DIANA is a solid-phase competitive binding assay that uniquely combines small molecule-based DIANA probes with the strengths of ELISA and qPCR, delivering robust quantitative potency data with an exceptionally broad dynamic range. This allows researchers to obtain precise binding affinity constants (Kd) from the start of their projects at a cost comparable to conventional methods that only provide relative inhibition.
DIANA Assay
DIANA assay measures potency of tested compound as function of its competition with DIANA probe. The assay delivers true binding constants (Kd) of test compound.
DIANA Assay
The amount of displaced DIANA probe is quantitatively determined by qPCR. qPCR readout ensures high dynamic range and enables calculation of Kd from a single measurement.
DIANA Assay
The DIANA Carbonic Anhydrase panel is the first commercially available tool that allows inhibitor profiling against all enzymatically active human isoforms.
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DIANA CA Panel | Collaboration
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