Junior Researcher: Oligonucleotide Synthesis

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Junior Researcher: Oligonucleotide Synthesis

About DIANA Biotechnologies

We are leading Czech biotechnology company with a great innovative potential. We focus on the development of products based on our cutting-edge research in the fields of molecular diagnostics and drug discovery. We have global ambitions and since our foundation in 2018 we already have achieved some of our goals. During COVID-19 pandemics, we were able to quickly develop one of the most innovative COVID-19 tests worldwide and we helped to increase the testing capacity of the whole country. As a result, we became the biggest Czech manufacturer of RT-PCR tests. Besides RT-PCR, we continue to focus on projects aiming to develop new molecular diagnostics, monoclonal antibodies and new drug candidates. This is possible thanks to our multidisciplinary team motivated to advance diagnostics and drug discovery.

We are a young and dynamic company being built by friendly and highly skilled colleagues, but at the same time we have already grown to a midsized company with around 100 employees and we have the ability to run long term and ambitious projects. If you join us, you will be part creation of a unique biotech company which is the first of its kind in the Czech Republic.

We are looking to build up our Oligonucleotide Synthesis team and are looking for a Junior Researcher: Oligonucleotide Synthesis.

What will be your responsibilities?

  • Developing and executing clear synthetic strategies towards chemically modified oligonucleotide sequences using state-of-the-art synthetic methodologies.
  • Optimization of protocols for synthetizing oligonucleotides on a commercial automated instrument.
  • Analyze screening data, perform literature reviews, design, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression (broadening the range of modifications (building blocks)).
  • Carry out a routine production of oligonucleotides for internal purposes.
  • All in cooperation with the Head of Chemistry and with the Analytical specialist.

Who are we looking for?

  • You finished Master or PhD degree in organic chemistry or related fields.
  • You have at least several years of relevant experience (time of PhD studies is counted).
  • Experience with solid phase oligonucleotide or nucleoside chemistry is welcomed but not necessary.
  • You have experience with anhydrous conditions reactions.
  • Knowledge of purification methods such as HPLC or GPC and LC-MS analysis is highly desirable.
  • You are self-motivated professional with positive attitude and team spirit, willing to work in multiple roles (working both as a researcher as well as a production specialist).

What do we offer?

  • Friendly and supportive environment.
  • Diverse work in a dynamic and unique biotech company.
  • Perspective of a long-term contract in a successful company.
  • Participation on the creation of unique inventions and products.
  • Support of further education, courses, trainings, thorough onboarding process.
  • Opportunity to join the company at an early stage enabling your career development.
  • Competitive salary and possibility of personal growth.
  • Various benefits, including five weeks paid vacation, sick days, MultiSport card, pension contribution and regular company events.
  • Full time employment contract.

Applications and further enquiries should be sent using the following form. 

When applying, please send us your motivation letter (tell us about your ambitions, project goals and skills you can contribute) and CV (incl. list of publications and at least two reference contacts).