Click chemistry ligands
The newest generation of water soluble Cu-catalyzed azide-alkyne cycloaddition (CuAAC) ligands, providing dramatic increase to the rate of click reaction. Reagents are synthesized in-house to support the development of DIANA probes, but are also available for purchase to support range of click chemistry applications.
#1 BTTP
3-(4-((bis((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)amino)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol
Purity: 99%+ (determined by UPLC-MS)
Molecular weight: 430.56
Pricing available on request
BTTP belongs to the newest generation water soluble CuI-catalyzed azide-alkyne cycloaddition (CuAAC) ligands, providing dramatic increase to the rate of click reaction. BTTP outperforms the most common click ligand catalysts such as THPTA and TBTA by a large margin1,2. It has been shown3, that BTTP is also an excellent ligand in cellular experiments, taking down the concentration of the toxic copper even lower.
1 Molecules 2016, 21, 1393; doi:10.3390/molecules21101393
2 Chem–Asian J. 2011;6:2796–2802. doi: 10.1002/asia.201100385
3 Angew. Chem. Int. Ed. 2011, 50, 1 – 7. doi: 10.1002/anie.201101817
#2 BTTPS
3-(4-((bis((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)amino)methyl)-1H-1,2,3-triazol-1-yl)propane-1-sulfonic acid
Purity: 99%+ (determined by UPLC-MS)
Molecular weight: 494.62
Pricing available on request
BTTPS belongs to the newest generation water soluble CuI-catalyzed azide-alkyne cycloaddition (CuAAC) ligands, providing dramatic increase to the rate of click reaction. BTTPS outperforms the most common click ligand catalysts such as THPTA and TBTA by a large margin1,2. It has been shown3, that BTTPS is also an excellent ligand when targeting the click reaction on the membrane, since it does not cross this barrier.
1 Molecules 2016, 21, 1393; doi:10.3390/molecules21101393
2 Chem–Asian J. 2011;6:2796–2802. doi: 10.1002/asia.201100385
3 Angew. Chem. Int. Ed. 2011, 50, 1 – 7. doi: 10.1002/anie.201101817
